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Invitrogen™ Human TBK1, GST Tag Recombinant Protein

Product Code. p-7121926
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Quantity:
10 μg
100 μg
Unit Size:
100µg
10µg
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Product Code. 15627888

Brand: Invitrogen™ A31513

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This purified recombinant full-length protein can be used in a number of different applications, but it has been specifically validated for use with both the LanthaScreen™ & Z'-LYTE™ assay technologies to identify novel kinase inhibitors. TBL1 is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen & Z'-LYTE assay technology Available in multiple pack sizes for convenient use Also available in our SelectSceen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active.

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9UHD2
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris HCl with 0.25mM DTT, 150mM NaCl, 25% glycerol, 0.1mM PMSF, 10mM glutathione, 0.1mM EDTA and no preservative; pH 7.5
Gene ID (Entrez) 29110
Molecular Weight (g/mol) 109.9 kDa
Name Human TBK1, GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1
Common Name TBK1
Gene Symbol TBK1
KinaseFamily CK1 Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Shipping Condition Dry Ice
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Full Length, Recombinant, Active
Form Liquid
Research Category Signal Transduction
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