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Invitrogen™ TDG Monoclonal Antibody (GT622)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA531519
This item is not returnable.
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Description
Keep as concentrated solution. Predicted reactivity: Human (99%), Mouse (88%), Rat (87%), Bovine (91%). Positive Control: human TDG-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Specifications
| TDG | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative | |
| Q13569 | |
| TDG | |
| Recombinant protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| GT622 | |
| Unconjugated | |
| TDG | |
| C-JUN leucine zipper interactive protein JZA-3; E130317C12Rik; G/T mismatch-specific thymine DNA glycosylase; hTDG; Jza1; JZA-3; Tdg; thymine DNA glycosylase; thymine-DNA glycosylase | |
| Mouse | |
| Protein G | |
| RUO | |
| 6996 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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