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Invitrogen™ TDP-43 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA529949
This item is not returnable.
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Description
Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, PC-12, Rat-2, Rat brain. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
Specifications
| TDP-43 | |
| Polyclonal | |
| Unconjugated | |
| TARDBP | |
| 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 230908, 23435, 298648 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ChIP sequencing (ChIP-seq), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry | |
| 0.63 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| Q13148, Q921F2 | |
| TARDBP | |
| Recombinant protein encompassing a sequence within the center region of human TDP43. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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