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Invitrogen™ TESPA1 Polyclonal Antibody

Description
Immunogen sequence: TNTETHPAKDE TFWKRKSRAR KSLFQKNLMG RKVKSLDLSI TQQKWKQSVD RPELRRSLSQ QPQDTFDLEE VQSNSEEEQS QSRWPSRPRH PHHHQT Highest antigen sequence identity to the following orthologs - mouse 25%, rat 26%.
TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species. TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage. TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus.
Specifications
Specifications
| Antigen | TESPA1 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.3 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | TESPA1 |
| Gene Accession No. | A2RU30 |
| Gene Alias | 5830405N20Rik; A430001F24Rik; AI450549; HSPC257; KIAA0748; LOW QUALITY PROTEIN: protein TESPA1; protein TESPA1; TESPA1; thymocyte expressed; thymocyte expressed, positive selection associated 1; thymocyte-expressed positive selection-associated protein 1 |
| Gene Symbols | TESPA1 |
| Show More |
Product Title
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