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Invitrogen™ TFF2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA534260
This item is not returnable.
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Description
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Marmoset, Dog (91%) Monkey, Mouse, Nematode (82%).
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
Specifications
| TFF2 | |
| Polyclonal | |
| Unconjugated | |
| Tff2 | |
| mSP; pancreatic spasmolytic polypeptide; PSP; SML1; SP; spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Tff2; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1) | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 7032 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 1 mg/mL | |
| PBS with 0.1% sodium azide | |
| Q03403 | |
| Tff2 | |
| Synthetic 11 amino acid peptide from internal region of human TFF2. | |
| 50 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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