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PeproTech TGF beta-3 Polyclonal Antibody, PeproTech®, Invitrogen™
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Product Code. 17845483
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Product Code. 17845483 Supplier PeproTech Supplier No. 500P3171MG

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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human TGF-beta3. Anti-Human TGF-beta3-specific antibody was purified by affinity chromatography employing an immobilized Human TGF-beta3 matrix. Western Blot: To detect Human TGF-beta3 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human TGF-beta3 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
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Specifications

Antigen TGF beta-3
Applications Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TGFB3
Gene Accession No. P10600
Gene Alias ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Gene Symbols TGFB3
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human TGF-beta3.
Purification Method Antigen affinity chromatography
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7043
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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