Invitrogen™ TGM2 Polyclonal Antibody

Description

Positive Samples: SW480, A-549, DU145, PC-3 Immunogen sequence: TNYNSAHDQN SNLLIEYFRN EFGEIQGDKS EMIWNFHCWV ESWMTRPDLQ PGYEGWQALD PTPQEKSEGT YCCGPVPVRA IKEGDLSTKY DAPFVFAEVN ADVVDWIQQD DGSVHKSINR SLIVGLKIST KSVGRDERED ITHTYKYPEG SSEEREAFTR ANHLNKLAEK EETGMAMRIR VGQSMNMGSD FDVFAHITNN TAEEYVCRLL LCARTVSYNG ILGPECGTKY LLNLNLEPFS GKALCSWSIC.

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.