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Invitrogen™ Themis Monoclonal Antibody (719945)
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Rat Monoclonal Antibody

Brand:  Invitrogen™ MA524337

Product Code. 15504032

  • € 463.00 / 100µg

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Description

Description

In Western blots, 100% cross-reactivity with recombinant human (rh) Themis (aa 2-282) is observed under non-reducing conditions, and approximately 10% cross-reactivity with rhThemis (aa 2-282) is observed under reducing conditions. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Themis is a cytoplasmic protein that is essential for positive selection and the development of single-positive thymocytes. Highest levels of expression are found in CD4+CD8+ double-positive thymocytes, with lower expression found in mature T cells. In addition to Grb1, Themis has been found to associate with PLC gamma 1 and LAT and is quickly phosphorylated by SLP-76 following TCR signaling. There are 5 isoforms of mouse Themis that are produced as a result of alternative splicing.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Themis
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q8BGW0
Themis
E. coli-derived recombinant mouse Themis Lys122-Lys237.
100 μg
Primary
Mouse
Antibody
IgG2b
Flow Cytometry, Western Blot
719945
Unconjugated
Themis
bA325O24.3; bA325O24.4; C6orf190; C6orf207; E430004N04Rik; FLJ40584; Gasp; GRB2-associated protein; Grb2-associating protein; MGC163388; Protein THEMIS; Protein thylex; RGD1560849; signaling phosphoprotein specific for T cells; SPOT; THEMIS; thylex; thymocyte expressed molecule involved in selection; thymocyte selection associated; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; Tsepa
Rat
Protein A/G
RUO
210757
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
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