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Invitrogen™ Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (JM33-20)
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Product Code. 16336144
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Quantity:
100 μL
Unit Size:
100µL
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16336144 100 μL 100µL
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Product Code. 16336144 Supplier Invitrogen™ Supplier No. MA532733

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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
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Specifications

Antigen Thymidylate Synthase
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JM33-20
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene TYMS
Gene Accession No. P04818, P07607, P45352
Gene Alias HST422; MGC88736; OK/SW-cl.29; Thymidylate synthase; thymidylate synthetase; TMS; TS; Tsase; Tyms; tysy
Gene Symbols TYMS
Host Species Rabbit
Immunogen Synthetic peptide within Human Thymidylate Synthase aa 264-313.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22171, 29261, 7298
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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