Invitrogen™ Thyroid Peroxidase Polyclonal Antibody

Description

Additional Information: This antibody is expected to recognize reported isoforms a (NP_000538.3), b (NP_783650.1), d (NP_78652.1), and e (NP_783653.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.