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Invitrogen™ TIGIT Recombinant Llama Monoclonal Antibody (2D7)
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Product Code. 17991201
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Quantity:
100 μg
Unit Size:
100µg
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17991201 100 μg 100µg
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Product Code. 17991201 Supplier Invitrogen™ Supplier No. MA549358

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Description

Llama Recombinant Monoclonal Antibody

TIGIT Recombinant Monoclonal Antibody for ICC/IF, IHC (P), Flow, ELISA

TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIGIT
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Recombinant Monoclonal
Clone 2D7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TIGIT
Gene Accession No. Q495A1
Gene Alias ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols TIGIT
Host Species Llama
Immunogen A recombinant protein corresponding to amino acids 22-141 of human TIGIT.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 201633
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype scFv
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