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  6. Invitrogen™ TIM-3 Recombinant Rabbit Monoclonal Antibody (024), Biotin, Invitrogen™

Invitrogen™ TIM-3 Recombinant Rabbit Monoclonal Antibody (024), Biotin, Invitrogen™
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Product Code. p-200063952
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30019495 100 μg 100µg
30019784 20 μg 20µg
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Product Code. 30019495 Supplier Invitrogen™ Supplier No. MA552197

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Description

Rabbit Recombinant Monoclonal Antibody

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
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Specifications

Antigen TIM-3
Applications ELISA
Classification Recombinant Monoclonal
Clone 024
Concentration 100 μg/mL
Conjugate Biotin
Formulation PBS with no preservative
Gene Havcr2
Gene Accession No. Q8TDQ0
Gene Alias CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
Gene Symbols Havcr2
Host Species Rabbit
Immunogen Recombinant Human TIMD3 protein (Ser 22-Arg200).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84868
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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