TIM-4 Rat anti-Mouse, PE, Clone: 54 (RMT4-54), eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-5866-82
Additional Details : Weight : 0.25000kg
DescriptionThe T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|SMUCKLER, TIM4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell membrane protein 4; TIM-4; TIMD-4|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.