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Invitrogen™ TNF beta Chimeric Recombinant Rabbit Monoclonal Antibody (3F12.2D3)
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Product Code. 17951071
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Quantity:
200 μg
Unit Size:
200µg
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17951071 200 μg 200µg
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Product Code. 17951071 Supplier Invitrogen™ Supplier No. MA548071

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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: 3F12 binds to human LT-alpha-3 and LT-alpha-Beta in both its soluble homotrimeric and membrane heterotrimeric forms. Preparation: 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LTalpha expressed in E. coli - the hybridoma clone was selected for its ability to bind LTalpha3 by ELISA. The CDRs of the antibody were grafted to the framework regions of the mice mAb 2G7 to create the chimeric version of the antibody.

TNF beta, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNF beta Chimeric
Applications ELISA, Flow Cytometry, Neutralization, Western Blot, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Clone 3F12.2D3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene LTA
Gene Accession No. P01374
Gene Alias DAMA-25N12.13; hlb382; hypothetical protein; LT; LT[a]; LT-[a]; LTA; LTalpha; LT-alpha; Ltx; lymphotoxin A; lymphotoxin alpha; lymphotoxin alpha (TNF superfamily, member 1); lymphotoxin-alpha; lymphotoxin-alpha; lymphotoxin alpha; TNF b; TNF beta; TNF superfamily, member 1; TNF β; Tnfb; TNFbeta; TNF-beta; TNF-N; Tnfsf1; Tnfsf1b; TNFβ; TNLG1E; tumor necrosis factor beta; tumor necrosis factor ligand 1E; tumor necrosis factor ligand superfamily member 1
Gene Symbols LTA
Host Species Rabbit
Immunogen 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LT-alpha expressed in E. coli.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4049
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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