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Invitrogen™ TNFAIP3 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA586684

Product Code. 16303555

  • € 520.00 / 100µL

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Description

Description

Purity is > 95% by SDS-PAGE.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TNFAIP3
Polyclonal
Unconjugated
TNFAIP3
A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
Rabbit
Antigen affinity chromatography
RUO
21929, 683206, 7128
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot, Immunocytochemistry, Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
P21580, Q60769
TNFAIP3
Synthetic peptide, corresponding to amino acids 365-410 of Human TNFAIP3.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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