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Invitrogen™ TOB1 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148982
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
Specifications
| TOB1 | |
| Polyclonal | |
| Unconjugated | |
| TOB1 | |
| APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; protein Tob1; Protein Tob1-like protein; TOB; TOB1; transducer of erbB2; Transducer of erbB-2 1; transducer of ERBB2, 1; transducer of ErbB-2.1; Trob; TROB1; Unknown (protein for MGC:134447) | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 10140 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P50616 | |
| TOB1 | |
| E. coli-derived recombinant human TOB1, Met1-Asn345. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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