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Invitrogen™ TOM70 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA582508
This item is not returnable.
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Description
Immunogen sequence: PLLSTQDFNM AADIDPQNAD VYHHRGQLKI LLDQVEEAVA DFDECIRLRP ESALAQAQKC FALYRQAYTG NNSSQIQAAM KGFEEVIKKF PRCAEGYALY AQALTDQQQF GKADEMYDKC IDLEPDNATT Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.
Specifications
| TOM70 | |
| Polyclonal | |
| Unconjugated | |
| TOMM70 | |
| 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; FLJ90470; KIAA0719; Mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; mKIAA0719; Tom70; Tomm70; Tomm70a; Translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); translocase of outer mitochondrial membrane 70 homolog A (yeast); translocase of outer mitochondrial membrane protein 70 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 28185, 9868 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O94826, Q9CZW5 | |
| TOMM70, Tomm70a | |
| Recombinant protein corresponding to Human TOMM70. Recombinant protein control fragment (Product #RP-90995). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Product Title
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