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Invitrogen™ Torc2 Monoclonal Antibody (5B10)

Product Code. 11375673
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
11375673 100 μL 100µL
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Product Code. 11375673 Supplier Invitrogen™ Supplier No. MA515710

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Description

Mouse Monoclonal Antibody

MA5-15710 targets CRTC2 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples. The MA5-15710 immunogen is purified recombinant fragment of human CRTC2 expressed in E. Coli. MA5-15710 detects CRTC2 which has a predicted molecular weight of approximately 80kDa.

CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Torc2
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5B10
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene CRTC2
Gene Accession No. Q53ET0
Gene Alias 4632407F12Rik; CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; CRTC2; mTORC2; OTTHUMP00000035255; RGD1308903; TORC2; TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein (CREB) 2; transducer of regulated cAMP response element-binding protein 2
Gene Symbols CRTC2
Host Species Mouse
Immunogen Purified recombinant fragment of human CRTC2 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 200186
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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