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Invitrogen™ TPMT Recombinant Rabbit Monoclonal Antibody (JE64-09)
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Product Code. 17886662
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Quantity:
100 μL
Unit Size:
100µL
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17886662 100 μL 100µL
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Product Code. 17886662 Supplier Invitrogen™ Supplier No. MA544759

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Description

Rabbit Recombinant Monoclonal Antibody

TPMT Recombinant Monoclonal Antibody for Western Blot, IHC (P), Flow

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
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Specifications

Antigen TPMT
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JE64-09
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TPMT
Gene Accession No. O55060, P51580, Q9Z0T0
Gene Alias AW106912; HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMTD; truncated thiopurine methyltransferase
Gene Symbols TPMT
Host Species Rabbit
Immunogen Synthetic peptide within human TPMT aa 101-150/245.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22017, 690050, 7172
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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