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Invitrogen™ TPT1 Polyclonal Antibody

Description
Recommended positive controls: mouse brain. Predicted reactivity: Mouse (95%), Rat (95%), Pig (100%), Rabbit (98%), Chicken (90%), Sheep (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%), Guinea pig (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
Specifications
Specifications
| Antigen | TPT1 |
| Applications | Western Blot |
| Classification | Polyclonal |
| Concentration | 0.54 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 |
| Gene | TPT1 |
| Gene Accession No. | P13693, P63028 |
| Gene Alias | 21 kDa polypeptide; 21 kDa polypeptide under translational control; fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p02; p21; p23; TCTP; Tpt1; translationally regulated transcript (21 kDa); translationally-controlled tumor protein; Trt; tumor protein, translationally-controlled 1 |
| Gene Symbols | TPT1 |
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