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Invitrogen™ TRAF5 Polyclonal Antibody

Product Code. 15694205
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Quantity:
100 μL
Unit Size:
100µL
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15694205 100 μL 100µL
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Product Code. 15694205 Supplier Invitrogen™ Supplier No. PA550278

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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TRAF5 protein.

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation (5).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TRAF5
Gene Accession No. O00463
Gene Alias 2700049M22Rik; AI875481; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; MGC:39780; p11 BID; p13 BID; p15 BID; p22 BID; RING finger protein 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; Traf5
Gene Symbols TRAF5
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human TNF receptor-associated factor 5.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7188
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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