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Invitrogen™ TRF2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA580104
This item is not returnable.
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Description
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat thymus tissue, human COLO320 whole cell. IHC: human tonsil tissue, human lung cancer tissue.
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Specifications
| TRF2 | |
| Polyclonal | |
| Unconjugated | |
| TERF2 | |
| Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 361403, 7014 | |
| -20°C | |
| Lyophilized |
| Immunohistochemistry (Paraffin), Western Blot | |
| 500 μg/mL | |
| PBS with 4mg trehalose and 0.05mg sodium azide | |
| Q15554 | |
| TERF2 | |
| E.coli-derived human TRF2 recombinant protein (Position: A81-K287). | |
| 100 μg | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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