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Invitrogen™ TRIM71 Polyclonal Antibody

Product Code. 12889152
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Quantity:
100 μg
Unit Size:
100µg
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12889152 100 μg 100µg
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Product Code. 12889152 Supplier Invitrogen™ Supplier No. PA521011

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-21011 can be used with blocking peptide PEP-1125. Antibodies should not be exposed to prolonged high temperatures.

TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM71
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRIM71
Gene Accession No. D3ZVM4, Q1PSW8, Q2Q1W2
Gene Alias 2610206G21Rik; abnormal cell LINeage LIN-41; AL022943; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; E3 ubiquitin-protein ligase TRIM71; Gm1127; homolog of C. elegans Lin-41; Lin41; LIN-41; lin-41 homolog; mLin41; mlin-41; protein lin-41 homolog; RGD1566388; RING-type E3 ubiquitin transferase TRIM71; Trim71; tripartite motif containing 71; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing 71; tripartite motif-containing protein 71
Gene Symbols TRIM71
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human TRIM71.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 131405, 301042, 636931
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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