Invitrogen™ TRPC3 Polyclonal Antibody

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Liver Tissue, Rat Lung Tissue, Rat Intestine Tissue, Rat Ovary Tissue, U87 whole cell, A549 whole cell, COLO320 whole cell, SW620 whole cell, HELA whole cell, rat brain tissue, mouse brain tissue, human Hela whole cell, human 22RV1 whole cell, human U-87MG whole cell, mouse Neuro-2a whole cell. IHC: Rat Brain Tissue, Human Rectal Cancer Tissue.

The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the 'canonical TRP' (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.