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Invitrogen™ TTBK2 Polyclonal Antibody
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Product Code. 15675185
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Quantity:
100 μL
Unit Size:
100µL
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15675185 100 μL 100µL
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Product Code. 15675185 Supplier Invitrogen™ Supplier No. PA551265

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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TTBK2 protein.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TTBK2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TTBK2
Gene Accession No. Q6IQ55
Gene Alias 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK
Gene Symbols TTBK2
Host Species Rabbit
Immunogen Synthetic peptide of human TTBK2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 146057
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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