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TYMS Mouse anti-Human, Clone: UMAB227, liquid, UltraMAB™

Product Code. 17500195
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Quantity:
30 μL
Unit Size:
30µL
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17500195 30 μL 30µL
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Product Code. 17500195 Supplier Origene Technologies Supplier No. UM870119

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Description

Mouse Monoclonal Antibody

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

Antigen TYMS
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone UMAB227
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene TYMS
Gene Accession No. P04818
Gene Alias HST422, TMS, TS
Gene Symbols TYMS
Host Species Mouse
Immunogen Full length human recombit protein of human TYMS (TS) produced in E.coli.
Purification Method Affinity Chromatography
Quantity 30 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7298
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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