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Invitrogen™ TYW1 Polyclonal Antibody
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Product Code. 15769221 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15769221 100 μL 100µL
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Product Code. 15769221 Supplier Invitrogen™ Supplier No. PA561407

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RELVDLIPEY EIACEHEHSN CLLIAHRKFK IGGEWWTWID YNRFQELIQE YEDSGGSKTF SAKDYMARTP HWALFGANER Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 85%.

TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TYW1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TYW1
Gene Accession No. Q9NV66
Gene Alias Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; radical S-adenosyl methionine and flavodoxin domains 1; RGD1310420; RSAFD1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW synthesizing protein 1 homolog; tRNA-yW synthesizing protein 1 homolog (S. cerevisiae); tRNA-yW synthesizing protein 1 homolog A; tRNA-yW-synthesizing protein; TYW1; TYW1A; YPL207W
Gene Symbols TYW1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TYW1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55253
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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