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Description
The E6-associated protein (E6-AP/UBE3A), a 100a protein, was originally identified as an ubiquitin-protein ligase (E3), in the presence of the E6 protein from human papillomavirus types 16 and 18. E6-AP has also been shown to function as a coactivator of steroid receptor-dependent transcriptional activity. Recent data indicate that the ubiquitin-protein ligase function of E6-AP is dispensable for its ability to coactivate nuclear hormone receptors, showing that E6-AP possesses two separable independent functions, as both a coactivator and a ubiquitin-protein ligase.
Specifications
Specifications
| Antigen | UBE3A |
| Applications | Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.33 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | UBE3A |
| Gene Accession No. | O08759, Q05086 |
| Gene Alias | ANCR, AS, E6 AP, E6AP, E6AP ubiquitin protein ligase, EPVE6AP, HPVE6A, UBE3A, ubiquitin protein ligase E3A |
| Gene Symbols | Ube3a |
| Show More |
Product Title
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