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Invitrogen™ UCH37 Polyclonal Antibody

Product Code. 15790171 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15790171 100 μL 100µL
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Product Code. 15790171 Supplier Invitrogen™ Supplier No. PA552223

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CTHQDVHLGE TLSEFKEFSQ SFDAAMKGLA LSNSDVIRQV HNSFARQQMF EFDTKT Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UCH37
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene UCHL5
Gene Accession No. Q9Y5K5
Gene Alias 5830413B11Rik; AD-019; CGI-70; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin C-terminal hydrolase 37; ubiquitin C-terminal hydrolase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5; UCH37; Uchl5; UCH-L5
Gene Symbols UCHL5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human UCH37. Recombinant protein control fragment (Product #RP-88752).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51377
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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