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UCHL5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11527-1-AP-20UL
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Description
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFbeta-dependent gene expression by de-ubiquinating and stabilizing TGFbeta RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.Specifications
| UCHL5 | |
| Polyclonal | |
| Unconjugated | |
| UCHL5 | |
| CGI 70, INO80R, Ubiquitin thioesterase L5, UCH L5, UCH37, UCHL5 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 360853, 51377, 56207 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin) | |
| 0.13 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| Q9WUP7, Q9Y5K5 | |
| UCHL5 | |
| UCHL5 Fusion Protein Ag2095 | |
| 20 μL | |
| Primary | |
| Rat, Mouse, Human | |
| Antibody | |
| IgG |
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