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Tocris Bioscience™ UNC 6934

Product Code. 18789166
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18789166 10 mg 10mg
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Product Code. 18789166 Supplier Tocris Bioscience™ Supplier No. 7183/10

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Description

Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization

UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2). UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC50 = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1. It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS 2561494-77-5
Quantity 10 mg
Target Lysine Methyltransferase Inhibitors
Molecular Formula C24H21N5O4
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