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Invitrogen™ UNC5B Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5140192
This item is not returnable.
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Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: SASLGSQQLL GLPRDPGSSV SGTFGCLGGR LSIPGTGVSL LVPNGAIPQG KFYEMYLLIN KAESTLPLSE Highest antigen sequence indentity to the following orthologs: Rat - 90%, Mouse - 91%.
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Specifications
| UNC5B | |
| Polyclonal | |
| Unconjugated | |
| UNC5B | |
| 6330415E02Rik; A630020F16; C. elegans; D10Bwg0792e; Netrin receptor UNC5B; p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 homolog 2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; Unc5b; UNC5H2; UNQ1883/PRO4326 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 219699 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8IZJ1 | |
| UNC5B | |
| Recombinant protein corresponding to Human UNC5B. Recombinant protein control fragment (Product #RP-109583). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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