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Uromodulin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16829293 Shop All Proteintech Products
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150 μL
Unit Size:
150µL
20µL
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16829293 150 μL 150µL
16839293 20 μL 20µL
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Product Code. 16829293 Supplier Proteintech Supplier No. 119111AP150UL

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Description

Rabbit Polyclonal Antibody

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal domit renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Specifications

Antigen Uromodulin
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene UMOD
Gene Accession No. P07911, P27590, Q91X17
Gene Alias ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, UMOD, uromodulin
Gene Symbols UMOD
Host Species Rabbit
Immunogen Uromodulin Fusion Protein Ag2494
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22242, 25128, 7369
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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