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USP5 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA501290
This item is not returnable.
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Description
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.Specifications
| USP5 | |
| Monoclonal | |
| 0.45 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P45974 | |
| USP5 | |
| Full length human recombit protein of human USP5 produced in HEK293T cell. | |
| 100 μL | |
| Primary | |
| Canine, Human, Rat | |
| Antibody | |
| IgG2a |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI2E3 | |
| Unconjugated | |
| USP5 | |
| ISOT | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 297593, 486718, 8078 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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