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TCR V alpha 11, APC, clone: RR8-1, eBioscience™

Rat Monoclonal Antibody

Merk:  Affymetrix eBioscience 17-5800-82

Overige gegevens : Gewicht : 0.25000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15330760

  • € 225.00 / 100 µg


Geschatte verzenddatum
bij leverancier 29-03-2019
Toevoegen aan winkelmandje

Beschrijving

Beschrijving

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specificatie

Specificatie

TCR V alpha 11
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
TCRV alpha 11; TCRV alpha11; TCR V alpha11; Valpha11; Va11
IgG2b, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
Mouse
Flow Cytometry
RR8-1
APC
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
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