missing translation for 'onlineSavingsMsg'
Learn More
Learn More
TCR V beta 10b Rat anti-Mouse, PE, Clone: B21.5, eBioscience™
Rat Monoclonal Antibody
Merk: Affymetrix eBioscience 12-5805-81
Overige gegevens : Gewicht : 0.25000kg
Beschrijving
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.Specificatie
TCR V beta 10b | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
Liquid | |
Rat | |
Affinity chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Mouse |
Flow Cytometry | |
B21.5 | |
PE | |
Tcrb | |
Tcrb | |
IgG2a, lambda | |
50 μg | |
4° C, store in dark, DO NOT FREEZE! | |
Primary | |
21577 |
For Research Use Only.