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Description
Indicated for the treatment of serious infections caused by methicillin-resistant strains. Vancomycin Hydrochloride, MP Biomedicals is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is
Vancomycin, from Streptomyces orientalis, block bacterial cell wall biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It also alters bacterial-cell-membrane permeability and RNA synthesis. It is widely studied in cancer patients.
Vancomycin is effective against Gram-positive bacteria. It is only indicated for the treatment of serious, life-threatening infections that are unresponsive to other less-toxic antibiotics. In particular, it is used to treat infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci bacteria. It should not be used to treat methicillin-sensitive Staphylococcus aureus, because it is inferior to penicillins such as nafcillin.
Specifications
Specifications
| Physical Form | Powder |
| CAS | 123409-00-7 |
| pH | 2.5 to 4.5 (5% aq. soln.) |
| Source | Streptomyces orientalis |
| Potency | ca. 1000μg/mg |
| Quantity | 100 mg |
| Molecular Formula | C66H257Cl2N9O24 |
| Solubility Information | Soluble in water (>100 mg/mL). Moderately soluble in dilute methanol. Insoluble in acetone, alcohols, and ether. |
| InChI Key | ARNOCQCQWLXLRG-UHFFFAOYSA-N |
| SMILES | C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.CC(C1=CC(=C(C=C1)OC2CC(C(C(O2)CO)O)O)OC3=CC=CC=C3)NC(=O)C.C(=O)O.N.N.N.N.N.N.N.N.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.Cl.Cl |
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Safety and Handling
- Vancomycin Hydrochloride
- Warning
- Skin sensitiser Category 1
- H317-May cause an allergic skin reaction.
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P321-Specific treatment (see on this label).
- P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
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