Invitrogen™ VEGF Receptor 1 Monoclonal Antibody (3D10)

Description

MA5-15550 targets FLT1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15550 immunogen is purified recombinant extracellular fragment of human FLT1 fused with hIgGFc tag expressed in HEK293 cells. MA5-15550 detects FLT1 which has a predicted molecular weight of approximately 100kDa.

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.