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Invitrogen™ Vimentin Monoclonal Antibody (SP20)
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Product Code. 13491137
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Quantity:
500 μL
Unit Size:
500µL
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Product Code. Quantity unitSize
13491137 500 μL 500µL
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Product Code. 13491137 Supplier Invitrogen™ Supplier No. MA516409

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393.68 EUR valid until 2026-04-10
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Description

Rabbit Monoclonal Antibody

Predicted to react with Rat, Hamster, Cow, and Xenopus laevis based on sequence homology. Recommended Postive Controls - WB: U-2 OS, Hu tonsil and HeLa cell lysates. Flow: HeLa cells. ICC/IF: HAP1-VIM cells, human limbal epithelial cells. IHC-P: Human breast cancer and melanoma tissue. IHC-Fr: Colorectal cancer tissue.

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Vimentin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone SP20
Concentration 0.006 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.20
Gene Vim
Gene Accession No. P08670, P20152
Gene Alias cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; Hel113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus
Gene Symbols Vim
Host Species Rabbit
Immunogen Recombinant human vimentin protein.
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22352, 7431
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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