missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ VISTA Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA547032
This item is not returnable.
View return policy
Description
In direct ELISAs, approximately 25% cross-reactivity with recombinant human VISTA/B7-H5/PD-1H is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.
Specifications
| VISTA | |
| Polyclonal | |
| Unconjugated | |
| VSIR | |
| 4632428N05Rik; B7H5; B7-H5; C10orf54; C1H10orf54; C28H10orf54; C4H10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1H; PDCD1 homolog; PD-H1; platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 74048 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 0.2 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| Q9D659 | |
| VSIR | |
| Mouse myeloma cell line NS0-derived recombinant mouse VISTA/B7-H5/PD-1H Phe33-Ala191. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction