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Invitrogen™ VPS34 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA585581
This item is not returnable.
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Description
Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (86%), Xenopus laevis (92%), Dog (99%), Pig (98%), Bovine (99%). Positive Control: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS, unboiled hVps34-transfected 293T cells. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. PIK3C3 phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes. PIK3C3 is involved in coupling nutrient signaling to mTOR and also plays a role in autophagy and intracellular trafficking. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.
Specifications
| VPS34 | |
| Polyclonal | |
| Unconjugated | |
| Pik3c3 | |
| 5330434F23Rik; catalytic phosphatidylinositol 3-kinase 3; catalytic subunit type 3 Antibody; class 3 phosphoinositide-3-kinase; Class III PI 3-kinase; hVps34; hVps34 Antibody; OTTMUSP00000023341; OTTMUSP00000023350; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-kinase catalytic subunit type 3; phosphatidylinositol 3-kinase p100 subunit; phosphatidylinositol 3-kinase, catalytic subunit type 3; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3K type 3; PI-3K Vps34p; pi3kc3; PI3-kinase type 3; Pik3c3; PIK3C3 Antibody; PtdIns-3-kinase type 3; VPS34 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 5289 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| Q8NEB9 | |
| Pik3c3 | |
| Recombinant protein encompassing a sequence within the N-terminus region of human VPS34. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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