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  6. VU 0240551, MedChemExpress

VU 0240551, MedChemExpress

Product Code. 16497128
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Product Code. 16497128 Supplier Medchem Express Supplier No. HY16689

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Description

MedChemExpress VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.

VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.

Specifications

Chemical Name or Material VU 0240551
Physical Form Solid
CAS 893990-34-6
Color White
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C16H14N4OS2
Solubility Information DMSO : ≥ 50 mg/mL (146.01 mM)
SMILES O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3
Molecular Weight (g/mol) 342.44
Formula Weight 342.44
Percent Purity 99.52%
Grade Research
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