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Tocris Bioscience™ VU 0409551
Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
Brand: Tocris Bioscience™ 5693/50
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Description
VU 0409551 is a selective mGlu5 positive allosteric modulator (EC50 = 260 nM). Selective for mGlu5 over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5 signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.Specifications
| [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone | |
| 1363281-27-9 | |
| JNJ 46778212 | |
| 50 mg |
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