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  5. Tocris Bioscience™ VU 0409551

Tocris Bioscience™ VU 0409551
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Product Code. 18794888
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18794888 50 mg 50mg
18747968 10 mg 10mg
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Product Code. 18794888 Supplier Tocris Bioscience™ Supplier No. 5693/50

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Description

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

VU 0409551 is a selective mGlu5 positive allosteric modulator (EC50 = 260 nM). Selective for mGlu5 over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5 signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.
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Specifications

Chemical Name or Material [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
CAS 1363281-27-9
Synonym JNJ 46778212
Quantity 50 mg
Target Group I mGluR Modulators
Molecular Formula C20H17FN2O3
Formula Weight 352.36
Purity >98%
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