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  5. Tocris Bioscience™ VU 6005649

Tocris Bioscience™ VU 6005649
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Product Code. 18709736
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Product Code. 18709736 Supplier Tocris Bioscience™ Supplier No. 6893/10

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Description

Positive allosteric modulators of mGlu7 and mGlu8 receptors. Also NK1 antagonist.

VU 6005649 is a positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65 μM and 2.6 μM for mGlu7 and mGlu8, respectively). Displays >3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 >10 μM for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4 μM). Brain penetrant.
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Specifications

Chemical Name or Material 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 2137047-43-7
Quantity 10 mg
Molecular Formula C16H12F5N3O
Purity 98%
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