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WIBG Monoclonal Antibody (OTI5E2), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA806496
This item is not returnable.
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Description
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo.Specifications
| WIBG | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9BRP8 | |
| PYM1 | |
| Full length human recombit protein of human WIBG produced in HEK293T cell. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI5E2 | |
| Unconjugated | |
| PYM1 | |
| PYM, WIBG | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 84305 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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