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Invitrogen™ XPG Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA561105
This item is not returnable.
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Description
Immunogen sequence: DDFSQYQLKG LLKKNYLNQH IEHVQKEMNQ QHSGHIRRQY EDEGGFLKEV ESRRVVSEDT SHYILIKGIQ AKTVAEVDSE SLPSSSKMHG MSFDVKSSPC E Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
Specifications
| XPG | |
| Polyclonal | |
| Unconjugated | |
| ERCC5 | |
| COFS 3; COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; DNA repair protein complementing XP-G cells homolog; ERCC 5; ERCC excision repair 5, endonuclease; ERCC5; ERCC5-201; ERCM 2; ERCM2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; OTTHUMP00000064902; RP11-484I6.5; UVDR; Xe; xeroderma pigmentosum; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; XPG; XPGC; XPG-complementing protein | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 2073 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| P28715 | |
| ERCC5 | |
| Recombinant protein corresponding to Human XPG. Recombinant protein control fragment (Product #RP-95290). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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