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  6. Invitrogen™ Zampilimab Recombinant Monoclonal Antibody

Invitrogen™ Zampilimab Recombinant Monoclonal Antibody
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Product Code. p-200111903
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. Quantity unitSize
30282595 100 μg 100µg
30284485 1 mg 1mg
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Product Code. 30282595 Supplier Invitrogen™ Supplier No. MA559813

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Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Zampilimab is a biosimilar that targets TGM2. Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zampilimab Humanized
Applications ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
Classification Recombinant Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 25 mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
Gene Alias UCB7858; UCB-7858
Host Species Human
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG4SP
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