missing translation for 'onlineSavingsMsg'
Learn More
Learn More
ZBTB4 Monoclonal Antibody (OTI1F6), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA811368
This item is not returnable.
View return policy
Description
The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determit of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.Specifications
| ZBTB4 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9P1Z0 | |
| ZBTB4 | |
| Human recombit protein fragment corresponding to amino acids 788-1013 of human ZBTB4 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI1F6 | |
| Unconjugated | |
| ZBTB4 | |
| KAISO-L1, ZNF903 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 57659 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction