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Invitrogen™ ZBTB4 Polyclonal Antibody
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Product Code. 17167113
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Quantity:
100 μL
Unit Size:
100µL
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17167113 100 μL 100µL
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Product Code. 17167113 Supplier Invitrogen™ Supplier No. PA5107311

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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 100%; Dog: 93%; Horse: 100%; Human: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
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Specifications

Antigen ZBTB4
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene ZBTB4
Gene Accession No. Q9P1Z0
Gene Alias 2310026P19Rik; 9230111I22Rik; KAISO-L1; KAISO-like zinc finger protein 1; Kiaa1538; mKIAA1538; Zbtb4; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing protein 4; ZNF903
Gene Symbols ZBTB4
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human ZBTB4.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57659
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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